She has screened and exhibited her work widely in the US and internationally, including: The Rotterdam Film Festival, Rotterdam, Netherlands; Deste Foundation for Contemporary Art, Athens, Greece.; LOOP Festival, Barcelona, Spain; Light Industry, Brooklyn, NY; Kusthalle Winterhur, Switzerland; Overgaden- Institute for Contemporary Art, Copenhagen, Denmark; iMOCA, Indianapolis, IN; Cinematexas, Austin, TX; Contemporary Art Center, Vilnius, Lithuania; Museo Nacional Centro De Arte Reina Sofia, Madrid; Whitney Museum of American Art (1997 Whitney Biennial), NY; Dunedin Public Art Gallery, New Zealand; MoMA PS1, LIC; Miami Museum of Contemporary Art, FL; and Brooklyn Museum, NY.

Her solo exhibitions include: LA><Art, LA, CA; Alma Enterprises, London, England; Locust Projects, Miami; Upstream Gallery, Amsterdam. Netherlands; Los Angeles Contemporary Exhibitions, LA; Participant Inc, NY and Deitch Projects, NY. She has had solo screenings at the Museum of Modern Art; NYC, The Kitchen, NYC; NY, CATE 10 Year Anniversary, Presented by the School of Art Institute of Chicago and Video Data Bank, Gene Siskel Film Center, Chicago Ill; Pacific Film Archive, Berkeley Art Museum, CA; Vtape, Toronto and in a two-person screening at the Museum of Modern Art, NY. She was presented by Participant Inc. in a two-person exhibition at No Soul for Sale at X Initiative, NYC, NY.

Parnes is a 2013 John Simon Guggenheim Memorial Fellow and has lectured as a visiting artist at numerous institutions including: Harvard University, Columbia University and UCLA. She has participated in panels at Yale University, the Solomon R. Guggenheim Museum and MoMA PSI. Parnes has held teaching positions at New York University, The New School and Bennington College. In 2012 she was a visiting critic at Yale University. She is currently teaching at graduate programs at MICA, Parsons, and SVA. She received her BFA from the Tyler School of Art, Temple University.